Chemists synthesize stable 3D molecules for drug design

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A research team at the University of Münster led by chemist Prof Frank Glorius has synthesized so-called heteroatom-substituted cage-like 3D molecules. The innovative structures could help address key challenges in drug design by serving as more stable alternatives to traditional, flat, aromatic rings.

As its name suggests, ring-shaped "cage molecules" resemble a cage, and it is this three-dimensional structure that makes them significantly more stable than related, flat molecules. Consequently, they could be of interest to drug developers as they represent a possible alternative to conventional molecular rings from the group of aromatic compounds.

The innovative structures are created by precisely inserting a triatomic unit into the strained (high-energy) ring of a reaction partner. The study is published in the journal Nature Catalysis.

Aromatic rings are flat rings in organic molecules. They are among the most common ingredients in pharmaceuticals and agrochemicals. However, these structures can be unstable under physiological conditions and thus hamper the effectiveness of pharmaceutical compounds. To solve this problem, scientists have been exploring complex three-dimensional alternatives—cage-like rings that are stiffer and thus more stable.

While such 3D substitutes for simple flat rings such as benzene (a ring with six carbon atoms) are already available, it has been much more difficult to synthesize 3D versions of flat rings that contain one or more other important atoms such as nitrogen, oxygen or sulfur. These so-called "heteroaromatic" rings are particularly common in drugs.

The breakthrough by the team from the University of Münster came by using bicyclobutane, a highly reactive molecule, and triggering the chemical reaction with light energy. "By using a light-sensitive catalyst, we were able to precisely insert nitrogen, oxygen and carbon atoms into this very reactive small bicyclic molecule which allowed us to synthesize a new type of 3D ring," explains Prof Glorius.

Previous studies mainly focused on inserting carbon atoms into the bicyclobutane. In contrast, inserting heteroatoms such as nitrogen and/or oxygen leads to new analogs of cage-like 3D rings.

"These new rings could potentially serve as a substitute for flat heteroaromatic rings in drug molecules, opening up new possibilities for drug development," says Dr. Chetan Chintawar. The synthesized rings are stable, versatile and can be easily modified, making them useful building blocks for creating numerous other cyclic molecules.

The researchers carried out experimental and computational studies to understand the mechanism of the reaction. They suggest that the reaction is initiated by the light-induced electron transfer event from the excited catalyst to the reactants delivering the final products.

More information: Chetan C. Chintawar et al, Photoredox-catalysed amidyl radical insertion to bicyclo[1.1.0]butanes, Nature Catalysis (2024). DOI: 10.1038/s41929-024-01239-9

Journal information: Nature Catalysis

Provided by University of Münster