Chemists synthesize stable 3D molecules for drug design
A research team at the University of Münster led by chemist Prof Frank Glorius has synthesized so-called heteroatom-substituted cage-like 3D molecules. The innovative structures could help address key ...
AI-designed DNA switches flip genes on and off, allowing precise activation or repression
Researchers at The Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence to design thousands of new DNA switches that can precisely control ...
Open-source tool enables a more complete and rapid decoding of the language of algal gene expression
A new method that research teams can use to measure and compare different forms of proteins and protein complexes helped reveal a previously unseen molecular signature of how algal genomes are controlled ...
A 'chemical ChatGPT' for new medications: Researchers train AI to predict potential active ingredients
Researchers from the University of Bonn have trained an AI process to predict potential active ingredients with special properties, deriving a chemical language model—a kind of ChatGPT for molecules. ...
P-stalk ribosomes identified as key regulators of immune evasion in cancer
Research uncovers how P-stalk ribosomes regulate cytokine responses, driving immune evasion in tumors across multiple cancer types. It offers new insights into post-translational mechanisms influencing immunotherapy success.
New insights into how gene transcription influences genome motion
A team of scientists has discovered surprising connections among gene activity, genome packing, and genome-wide motions, revealing aspects of the genome's organization that directly affect gene regulation and expression.
3D imaging study shows how geometric mechanics shape the dog's nose
The noses of many mammals, such as dogs, ferrets and cows, feature grooves forming a multitude of polygons. A team from the University of Geneva (UNIGE) has analyzed in detail how these patterns form ...
New fingerprint mass spectrometry method paves the way to solving the proteome
Caltech scientists have developed a method driven by machine learning that allows them to accurately measure the mass of individual particles and molecules using complex nanoscale devices. The new technique ...
Geometric mechanics shape the dog's nose
The noses of many mammals, such as dogs, ferrets and cows, feature grooves forming a multitude of polygons. A team has analyzed in detail how these patterns form in the embryo using 3D imaging techniques and computer simulations. The researchers discovered that differential growth of the skin tissue layers leads to the formation of domes, which are mechanically supported by the underlying blood vessels. This work describes for the first time this morphogenetic process, which could help explain the formation of other biological structures associated with blood vessels.
Lab-grown human brain cells drive virtual butterfly in simulation
Could organoid-driven computing be the future of AI power?
New fingerprint mass spectrometry method paves the way to solving the proteome
A new data-driven technique, called fingerprint mass spectrometry, provides a method for measuring the mass of individual proteins using nanoscale devices.
Nobel-winning Google AI reveals intimate hook up of sperm and egg
The research, published recently, uses AlphaFold-Multimer, a Nobel-winning AI tool that predicts how proteins interact.
Optibrium demonstrates superior molecular docking method for small molecules and macrocycles
Optibrium, a leading developer of software and AI solutions for molecular design today announced the publication of a peer-reviewed study in the Journal of Computer-Aided Molecular Design, 'Structure-Based Pose Prediction: Non-cognate Docking Extended to Macrocylic Ligands'.
Scientists uncover how transcription drives motion within the genome
A team of scientists has discovered surprising connections among gene activity, genome packing, and genome-wide motions, revealing aspects of the genome's organization that directly affect gene regulation ...
Stirred, not shaken: Scientists uncover how transcription drives motion within the genome
A team of scientists has discovered surprising connections among gene activity, genome packing, and genome-wide motions, revealing aspects of the genome's organization that directly affect gene regulation and expression. The findings bolster our understanding of the mechanics behind transcription-dependent motions of single genes -- the dysfunction of which may lead to neurological and cardiovascular disorders as well as to cancer.
last updated on 23 Oct 20:27