A team of researchers from City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S., and The University of Texas M.D. Anderson Cancer Center, have reported safety and efficacy results from a Phase 1 trial that featured a personalized vaccine to treat lymphoplasmacytic lymphoma, a rare and slow-growing type of blood cancer, according to a study published recently in Nature Communications.

Researchers discovered that IBD significantly increases the risk of developing T1D, and this association works both ways, independent of genetics and familial factors. The strongest link was seen in ulcerative colitis patients.

The failure to diagnose Alzheimer's disease, the most common form of dementia in the elderly, at an early stage of molecular pathology is considered a major reason why treatments fail in clinical trials. Previous research to molecularly diagnose Alzheimer's disease yielded "A/T/N" central biomarkers based on the measurements of proteins, β-amyloid ("A") and tau ("T"), and "N" encompassing neurodegeneration. A/T/N can be measured in brain tissue, by in vivo brain imaging techniques, and by analysis of cerebrospinal fluid and plasma.

New research is more closely linking obesity to dementia. Higher levels of leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged adults, according to a study by The University of Texas Health Science Center at San Antonio (UT Health San Antonio).

A new study helps explain why having ApoE4—the gene variant most closely linked to Alzheimer's disease—increases the risk of neurodegeneration and white matter damage.

Scientists have pinpointed thousands of genetic changes in a gene that may increase a person's risk of developing breast and ovarian cancer, paving the way for better risk assessment and more personalised care.

In his doctoral dissertation completed at the University of Jyväskylä, Finland, Tero Sievänen demonstrates that the cancer risk of Lynch syndrome carriers can be assessed based on circulating microRNA profiles.

In a recent study published in the scientific journal "Blood", researchers from MedUni Vienna show that hemorrhages are more common in cancer patients than previously thought and are associated with a poor prognosis and an increased risk of death.

Macquarie University researchers have discovered new information about how oral cancer cells may block the body's immune response. This could lead to better treatments for this aggressive disease.

Arrhythmias, a group of disorders that disrupt the normal rhythm of the heart, can lead to serious health complications such as heart failure, stroke, and sudden death.