Researchers uncover the potential of JAK inhibitors to treat life-threatening skin disease
Researchers identified Janus kinase inhibitors as a promising treatment for the severe drug-induced skin condition toxic epidermal necrolysis, by analyzing patient biopsies with deep visual proteomics.
ALS drug shows promise in targeting glioblastoma stem cells
Glioblastoma is the most common – and the most malignant – primary brain tumour in adults. It's aggressive and incurable.
Study identifies biomarkers for immunotherapy success in liver cancer
It may soon be possible to determine which patients with a type of liver cancer called hepatocellular carcinoma would benefit from immunotherapy, according to a preclinical study by Weill Cornell Medicine investigators.
New compounds from fungi show promise in treating colorectal cancer
Novel chemical compounds from a fungus could provide new perspectives for treating colorectal cancer, one of the most common and deadliest cancers worldwide.
Innovative sensor material offers non-invasive cancer diagnosis
A research team led by Dr. Ho Sang Jung of the Advanced Bio and Healthcare Materials Research Division at the Korea Institute of Materials Science has developed an innovative sensor material that amplifies the optical signals of cancer metabolites in body fluids (saliva, mucus, urine, etc.) and analyzes them using artificial intelligence to diagnose cancer.
Biofilms study reveals how multiple bacteria species manage to coexist
Biofilms—slimy communities of bacteria—grow on all sorts of surfaces: from glaciers and hot springs to plant roots, your bathtub and fridge, wounds, and medical devices such as catheters. Most biofilms ...
Microbiome studies in humans and zoo animals pave the way for new drug development
Microorganisms do not just colonize the body of mammals during infections. Billions of microbes can be found on and in healthy humans and animals at any given time, communicating with each other via chemical ...
Trial evaluates monoclonal antibodies for long COVID prevention
The first randomized, placebo-controlled clinical trial evaluating the impact of therapeutic monoclonal antibodies on the risk of developing long COVID was led by researchers at Weill Cornell Medicine.
Pathogenic system found on Providencia rustigianii has virulence gene akin to Salmonella's
Salmonella and E. coli are well-known bacteria that cause food poisoning, but less understood are species of Providencia, another causative agent of serious symptoms.
Plant fungus provides new drug target for colorectal cancer therapy
Novel chemical compounds from a fungus could provide new perspectives for treating colorectal cancer, one of the most common and deadliest cancers worldwide.
Black prostate cancer patients respond better to immunotherapy
Black men with advanced prostate cancer have a greater chance of survival after immunotherapy treatment, at least in part, because of ancestral gene variants in immune responses.
A mushroom for colorectal cancer therapy
Novel chemical compounds from a fungus could provide new perspectives for treating colorectal cancer, one of the most common and deadliest cancers worldwide. Researchers have reported on the isolation and characterization of a previously unknown class of metabolites (terpene-nonadride heterodimers). One of these compounds effectively kills colorectal cancer cells by attacking the enzyme DCTPP1, which thus may serve as a potential biomarker for colorectal cancer and a therapeutic target.
Adenine base editors show potential to correct X-CGD-causing mutations
A collaborative effort between investigators at the National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID) and Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, demonstrates the potential of precise genome editing technologies, called adenine base editors, to correct disease-causing mutations in stem cells from patients with X-linked chronic granulomatous disease (X-CGD), a rare genetic disorder characterized by high susceptibility to infections.
Biomarker may predict immunotherapy response in liver cancer
It may soon be possible to determine which patients with a type of liver cancer called hepatocellular carcinoma would benefit from immunotherapy, according to a preclinical study.
FDA-approved breast cancer drug shows promise for appendix cancer
Researchers at University of California San Diego School of Medicine found an FDA-approved drug used to treat breast cancer has the potential to be an effective therapeutic for a specific type of appendix cancer.
Groundbreaking discovery offers hope for patients suffering from toxic epidermal necrolysis
A global team of researchers at the Max Planck Institute of Biochemistry has made a groundbreaking discovery that saves the lives of patients suffering from toxic epidermal necrolysis.
Immunotherapy sets new standard for Hodgkin lymphoma care
A treatment that rallies the immune system to destroy cancer raised the survival rate for advanced Hodgkin lymphoma patients to a remarkable 92 percent, suggesting a new standard therapy for the disease.
Microbiome: Drug discovery within the patient
Microorganisms do not just colonize the body of mammals during infections. Billions of microbes can be found on and in healthy humans and animals at any given time, communicating with each other via chemical signals and thus influencing their health. In two studies, researchers have now conducted a detailed study of the microbiome, i.e. the totality of all microorganisms, in humans and zoo animals. The aim was to identify starting points for strategies for the treatment and diagnosis of diseases.
Nanoparticle therapy offers new hope for prostate cancer patients
Prostate cancer is the second leading cause of cancer death among American men. A recent study, conducted by researchers from the University of Virginia, Mount Sinai, the University of Michigan, the University ...
New mRNA vaccine created to prevent and treat C. difficile
A new vaccine provides hope for treating and even preventing the highly contagious and difficult-to-treat Clostridioides difficile infection, more commonly known as C. difficile or C. diff. In animal models, this first mRNA-LNP C. difficile vaccine was found to protect against C. difficile first-time infections and relapsing infections by inducing a robust immune response, promote clearance of existing C. diff bacteria from the gut, and even overcome deficits in host immunity to protect animals after infection, according to researchers. The results will pave the way for clinical trials of the vaccine.
last updated on 18 Oct 06:25