ECOG-ACRIN and Caris Life Sciences launch collaborative cancer research initiative

The TAILORx project will explore early-stage breast cancer, where the risk of recurrence is a primary concern for many people. According to the American Cancer Society, breast cancer remains the most common cancer overall, with approximately 310,720 new cases in the United States annually. Approximately 60% of these new cases are in the early stage (no spread to surrounding lymph nodes). While there has been an overall 42% decline in breast cancer deaths over the last 30 years-;due to increased use of mammograms, earlier diagnoses, and more effective treatments-;there is a persistent mortality gap between minority patients and white patients. A TAILORx analysis published in JAMA Surgery is the first to show that racial and ethnic differences in locoregional breast cancer recurrence patterns are prevalent even in a clinical trial population with similar access to care.

George W. Sledge, Jr., MD, EVP and Chief Medical Officer of CarisI'm excited to build on the trial's initial findings which prevented millions of women with early breast cancer from having to endure toxic treatments, to continue discerning valuable insights related to long term recurrence risk and to identify even more women who may benefit from more efficient treatment options. It is truly a full circle moment for me, as I've been involved with this landmark biomarker trial–the largest ever sponsored by the NCI–during trial development, patient enrollment, findings reporting and now the next phase of research of TAILORx with Caris."

Additionally, ECOG-ACRIN joined the Caris Precision Oncology Alliance™ (Caris POA), a global network of leading cancer centers and research consortia that collaborate to advance precision oncology and biomarker-driven research, with its members working together to establish and optimize standards of care for molecular testing through innovative research to improve clinical outcomes for cancer patients.

"Our shared vision of improving the outcomes of all patients with cancer will nurture this collaborative effort with the ECOG-ACRIN researchers. We aim to achieve common goals in advancing precision medicine and biomarker research in cancer, and to increase treatment options for cancer patients," said Sledge of ECOG-ACRIN joining the Caris POA.

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ECOG-ACRIN Cancer Research Group