Georgia Tech researchers create lab-grown models of human immune systems

"For the first time, we can recreate and sustain complex immunological processes in a synthetic gel, using blood, and effectively track B cell responses," he added. "This is a gamechanger for understanding and treating immune vulnerabilities in patients with lymphoma who have undergone cancer treatment -; and hopefully other disorders too."

Designing a tiny immune system model

The models also enable researchers to control and test immune responses under various conditions. The team discovered that not all tissue sources are the same, and tonsil cells struggled with longevity issues. They used a specialized setup to study how healthy immune cells react to signals that help them fight infections, which failed to trigger the same response in cells from lymphoma survivors who seemingly have recovered from immunotherapy treatment.

A game-changing technology

"This technology provides deeper biological insights and an innovative way to monitor for recovery of immunological defects over time. It could help clinicians better identify patients who would benefit from specific interventions that reduce infection risk," Koff added.

Source:

Georgia Institute of Technology

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