Giants vs. Cowboys odds, prediction, time, spread: Thursday Night Football picks by NFL model on 42-22-run

SportsLine's model simulated Dallas Cowboys vs. New York Giants on Thursday Night Football 10,000 times

The New York Giants will try to flip the script on the Dallas Cowboys when they meet in a key NFC East matchup on Thursday Night Football. Dallas has dominated New York for nearly a decade, winning 13 of the last 14 meetings, including six in a row. The Cowboys (1-2), who have stumbled out of the gate after winning the division a year ago, have won 12 regular-season games in each of the past three years. The Giants (1-2), who finished third in the NFC East a year ago at 6-11, have been outscored 89-17 in the last two meetings with Dallas.

Kickoff from MetLife Stadium in East Rutherford, N.J., is set for 8:15 p.m. ET. The Cowboys are 5.5-point favorites in the latest Giants vs. Cowboys odds, while the over/under for total points scored is 45.5. Before making any Cowboys vs. Giants picks, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2024 NFL season on an incredible 188-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 42-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.    

Now, the model has set its sights on Cowboys vs. Giants and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and NFL betting lines for the spread, money line and over/under for Giants vs. Cowboys: 

• Giants vs. Cowboys spread: Dallas -5.5
• Giants vs. Cowboys over/under: 45.5 points
• Giants vs. Cowboys money line: Dallas -261, New York Giants +213
• DAL: Cowboys are 5-5 on the road since the start of 2023
• NYG: Giants are 4-5 at MetLife Stadium since the beginning of last season
• Giants vs. Cowboys picks: See picks at SportsLine

Why you should back the Cowboys

Dallas kicker Brandon Aubrey made history in last Sunday's loss to the Ravens when he converted a 65-yard field goal in the first quarter. It is the second-longest field goal in league history, trailing only Justin Tucker, who connected on a 66-yarder on Sept. 26, 2021. Aubrey, who hit on a 60-yard field goal on Dec. 10, 2023, is the eighth kicker in NFL history with multiple made field goals of at least 60 yards. For the season, he has connected on 10 field goals and five extra points for a team-high 35 points.

Defensively, linebacker Eric Kendricks has led the defense with a team-high 29 tackles, including 14 solo. He also has registered two sacks for eight years, and one tackle for loss. He has knocked down one pass and intercepted another. The 10-year veteran, a former second-rounder by the Minnesota Vikings in 2015, has registered 1,065 career tackles, including 672 solo, with 20.5 sacks, five forced fumbles and six fumble recoveries. See which team to pick here.

Why you should back the Giants

New York has a one-two punch at wide receiver. Rookie Malik Nabers leads the team with 23 receptions for 271 yards (11.8 average) and three TDs. He also has six explosive plays of 20 or more yards, including a long of 28 yards. He has 127 yards after the catch with 14 first-down conversions.

Also leading the receiving corps is third-year veteran Wan'Dale Robinson. The former second-round pick has 15 receptions for 123 yards (8.2 average) and one touchdown. He has a long reception of 20 yards with 63 yards after the catch and eight first-down conversions. In Sunday's win at Cleveland, Robinson caught seven passes for 61 yards. See which team to pick here.

How to make Cowboys vs. Giants picks

SportsLine's model is leaning Under the total, projecting 44 points. It also says one side of the spread has all the value. You can only get the NFL model's picks at SportsLine.

So who wins Cowboys vs. Giants on Thursday Night Football, and which side of the spread has all the value? Visit SportsLine now to see which side of the Cowboys vs. Giants spread to jump on, all from the advanced model that is up well over $7,000 on its NFL picks, and find out.