Seahawks vs. 49ers odds, prediction, time, spread: Thursday Night Football picks from NFL model on 45-23 roll

SportsLine's model simulated San Francisco 49ers vs. Seattle Seahawks on Thursday Night Football 10,000 times

Teams looking to turn their recent fortunes around clash when the San Francisco 49ers face the Seattle Seahawks in a key NFC West matchup on Thursday Night Football. San Francisco is coming off a 24-23 loss to the Arizona Cardinals on Sunday, while Seattle dropped a 29-20 decision to the New York Giants. The 49ers (2-3), tied for second in the division with the Cardinals, have lost three of their last four games. The Seahawks (3-2), first in the NFC West, are on a two-game losing streak.

Kickoff from Lumen Field in Seattle is set for 8:15 p.m. ET. The 49ers are 3.5-point favorites in the latest Seahawks vs. 49ers odds via SportsLine Consensus, while the over/under for total points scored is 49. Before making any 49ers vs. Seahawks picks, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2024 NFL season on an incredible 10-2 hot streak on top-rated NFL picks this year. Longer term, it is on a 191-131 roll on top-rated NFL picks that dates back to the 2017 season and a 45-23 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.    

Now, the model has set its sights on 49ers vs. Seahawks and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and NFL betting lines for the spread, money line and over/under for Seahawks vs. 49ers: 

• Seahawks vs. 49ers spread: San Francisco -3.5
• Seahawks vs. 49ers over/under: 49 points
• Seahawks vs. 49ers money line: San Francisco -178, Seattle +148
• SF: 49ers are 2-3 against the spread this season
• SEA: Seahawks are 1-3-1 ATS in 2024
• Seahawks vs. 49ers picks: See picks at SportsLine

Why you should back the 49ers

Quarterback Brock Purdy has been solid through five games this season. He has completed 103 of 157 attempts (65.6%) for 1,374 yards and six touchdowns with four interceptions for a 95.3 rating. He is also second on the team in rushing, carrying 22 times for 108 yards (4.9 average) and 11 first-down conversions. His best effort came in a 27-24 loss to the Los Angeles Rams on Sept. 22. He completed 22 of 30 passes (73.3%) for 292 yards and three touchdowns.

Running back Jordan Mason leads the ground attack in the absence of Christian McCaffrey (Achilles). In five games, he has carried 105 times for 536 yards (5.1 average) and three touchdowns. He has had six explosive plays of 20 or more yards, including a long of 36 yards. He has had three 100-yard rushing games, including a 28-carry, 147-yard and one-TD effort in the season-opening win over the New York Jets on Sept. 9. See which team to pick here.

Why you should back the Seahawks

Quarterback Geno Smith propels the Seattle offense. He has completed 71.9% of his passes for 1,466 yards and five touchdowns with four picks and a 92.7 rating. Smith has also carried 20 times for 146 yards (7.3 average) and one touchdown. He has three explosive plays of 20 or more yards, including a long of 34 yards. He has thrown for more than 300 yards twice, including a 395-yard performance in a 42-29 loss at Detroit on Sept. 30.

Wide receiver DK Metcalf continues to be explosive in the passing game. He has 28 receptions for a team-high 421 yards (15.0 average) and two touchdowns. He has seven plays of 20-plus yards, including a long of 71. He has 154 yards after the catch and has converted 13 first downs. In a 23-20 overtime win at New England on Sept. 15, he caught 10 passes for 129 yards with one touchdown. See which team to pick here.

How to make 49ers vs. Seahawks picks

SportsLine's model is leaning Over the total, projecting 51 total points. It also says one side of the spread cashes in well over 50% of simulations. You can only get the NFL model's picks at SportsLine.

So who wins 49ers vs. Seahawks on Thursday Night Football, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the 49ers vs. Seahawks spread to jump on, all from the advanced model that is up well over $7,000 on its NFL picks, and find out.