Self-learning AI shares NFL against the spread, over-under, money-line picks for every Week 6, 2024 game

SportsLine AI evaluated the Week 6 NFL odds and revealed its NFL predictions, NFL score predictions, and NFL betting picks for every game

The Texans are 4-1 after holding off a comeback from the Bills last week, but Houston suffered a heavy loss in the process. Star receiver Nico Collins suffered a hamstring injury in the first half and did not return. However, the Texans are still one of the biggest favorites in the Week 6 NFL odds, as they are spotting the Patriots seven points on the road this Sunday. Meanwhile, the Bills will try to rebound in a critical AFC East matchup against the New York Jets on Monday Night Football, and Buffalo is favored by 2.5.

How should you play NFL spreads, NFL totals, and NFL money-lines and how can having exact Week 6 NFL score predictions aid those efforts? Before you make any Week 6 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI PickBot has nailed 128 4-star picks or better this season and hit a whopping 1,674 4.5- and 5-star prop picks last season. Anyone who has followed it is way up.

For Week 6 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 14 games. You can only see the AI predictions for the Week 6 NFL schedule here.

Top Week 6 NFL AI picks

After analyzing every game in Week 6, the AI PickBot says the Broncos cover as 3-point home underdogs against the Chargers. These are the league's two top-ranked scoring defenses and the Chargers have had an extra week off to prepare but the AI PickBot very clearly feels that Denver's undervalued here at home after a dominant win over the Raiders.

The Broncos forced three turnovers against Las Vegas and their 3.8 sacks per game ranks third in the NFL this season. Chargers quarterback Justin Herbert had to leave a loss against Kansas City because he aggravated an ankle injury he was playing through and his mobility will likely be an issue once again on Sunday. That's a big reason why the AI PickBot is predicting Denver wins outright by an average final score of 20.41-17.91. See its other Week 6 football predictions and football picks at SportsLine.

How to make Week 6 NFL picks

In addition, the AI PickBot has generated 14 other A-rated picks for Week 6, including two with a coveted A+ grade. You need to see the AI PickBot's NFL picks before making any Week 6 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 6 NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that has nailed 128 top-rated picks this season.