Jacksonville State vs. Liberty prediction, odds: 2024 college football picks, bets by expert on 191-112 run

SportsLine's Jimmie Kaylor revealed his Week 10 CFB picks and predictions for the Liberty Flames vs. Jacksonville State Gamecocks game on Wednesday at Williams Stadium

The Liberty Flames (5-1, 3-1) look to bounce back from a shocking upset loss when they host the Jacksonville State Gamecocks (4-3, 3-0) in a mid-week Conference USA matchup on Wednesday. Liberty lost to Kennesaw State 27-24 in its last outing, giving the Owls the program's first win over a FBS opponent. The loss was crippling to the Flames' College Football Playoff hopes, but the conference title is still up for grabs. The Gamecocks have won four straight games, with each win coming in blowout fashion. Jacksonville State beat Middle Tennessee State 42-20 in its last outing.

Kickoff in Lynchburg, Va., is scheduled for 7 p.m. ET on CBS Sports Network. The Flames are favored by 2.5 points in the latest Liberty vs. Jacksonville State odds via SportsLine consensus, while the over/under is 64 points, up half a point from the opener. Before making any Jacksonville State vs. Liberty picks, you need to see the Week 10 college football predictions and betting advice from SportsLine's Jimmie Kaylor. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big on sports betting apps for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, netting a whopping 71.1 units while posting a 191-112-3 record since Week 1 of the 2023 season. All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks is way up.

Now, Kaylor has dialed in on Liberty vs. Jacksonville State on Wednesday and just revealed his college football picks and predictions. You can head to SportsLine now to see his picks. Here are the college football odds and betting lines for Jax State vs. Liberty:

• Jacksonville State vs. Liberty spread: Liberty -2.5
• Jacksonville State vs. Liberty over/under: 64 points 
• Jacksonville State vs. Liberty money line: Liberty -134, Jacksonville State +113
• Jacksonville State vs. Liberty picks: See picks at SportsLine
• Jacksonville State vs. Liberty streaming: FuboTV (Try for free)

Why Jacksonville State can cover

Jacksonville State has been on a roll over the last month, playing its best football of the season. The Gamecocks have won four consecutive games, with each win coming by an average of 34.8 points. Jax State is also 4-0 against the spread during its winning streak. 

The Gamecocks have the top ranked offense in Conference USA. They enter Wednesday leading the conference averaging 465.9 total yards per game, 256.3 rushing yards per game, and 39.7 points per game. Running back Tre Stewart leads the way for the Gamecocks with 682 rushing yards and 11 rushing touchdowns. See which team to pick here. 

Why Liberty can cover

Like Jacksonville State, Liberty has been dominant on offense, specifically running the ball, in 2024. The Flames enter this matchup averaging 222.5 rushing yards and 31.8 points per game, second only to Jax State in the C-USA rankings. Defensively, Liberty also ranks near to top of the conference in all major defensive categories. 

Quarterback Kaidon Salter gives the Flames an advantage at the most important position on the field. The 6-foot-1 junior is widely viewed as a future NFL Draft pick and could have a field day against the Jacksonville State defense. Salter enters this matchup with 1,280 passing yards, 10 touchdown passes, and two interceptions and he's rushed for 278 yards and two scores. See which team to pick here.

How to make Liberty vs. Jacksonville State picks

Kaylor has analyzed Jax State vs. Liberty from every angle and he's leaning Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

So who wins Liberty vs. Jacksonville State on Wednesday, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the expert who has profited $7,110 for $100 college football bettors since Week 1 of 2023 season, and find out.