Giants vs. Cowboys odds, prediction, time, spread: Thursday Night Football picks by NFL model on 42-22-roll

SportsLine's model simulated Dallas Cowboys vs. New York Giants on Thursday Night Football 10,000 times

Teams in desperate need for a second win on the season will meet when the Dallas Cowboys face the New York Giants in an NFC East showdown on Thursday Night Football. The Cowboys (1-2), who are hoping to snap a two-game losing streak, won the division a year ago with a 12-5 mark. The Giants (1-2), who are looking to win their second game in a row, finished third in the NFC East in 2023 with a 6-11 mark. Dallas has dominated the series of late, having won six consecutive games, outscoring the Giants 89-17 in two games last season.

Kickoff from MetLife Stadium in East Rutherford, N.J., is set for 8:15 p.m. ET. The Cowboys are 5.5-point favorites in the latest Giants vs. Cowboys odds, while the over/under for total points scored is 45.5. Before making any Cowboys vs. Giants picks, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2024 NFL season on an incredible 188-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 42-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.    

Now, the model has set its sights on Cowboys vs. Giants and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and NFL betting lines for the spread, money line and over/under for Giants vs. Cowboys: 

• Giants vs. Cowboys spread: Dallas -5.5
• Giants vs. Cowboys over/under: 45.5 points
• Giants vs. Cowboys money line: Dallas -241, New York Giants +198
• DAL: Cowboys are 5-5 on the road since the start of 2023
• NYG: Giants are 4-5 at MetLife Stadium since the beginning of last season
• Giants vs. Cowboys picks: See picks at SportsLine

Why you should back the Cowboys

Ninth-year veteran quarterback Dak Prescott continues to be the key to Dallas' offense. In last Sunday's loss to the Baltimore Ravens, he completed 28 of 51 passes (54.9%) for 379 yards and two touchdowns. He also carried twice for seven yards and a score. For the season, he has connected on 60.7% of his passes for 851 yards and four touchdowns with two picks and an 85.8 rating.

The rushing attack is led by the combination of veteran running backs Rico Dowdle and Ezekiel Elliott. Dowdle is the top rusher, carrying 23 times for 88 yards (3.8 average), and has caught eight passes for 59 yards (7.4 average). Elliott, meanwhile, has 19 carries for 62 yards (3.3 average) and one touchdown. He also has five receptions for 31 yards (6.2 average). See which team to pick here.

Why you should back the Giants

Running back Devin Singletary is off to a solid start to the season as he takes over for Saquon Barkley, who is now with the rival Philadelphia Eagles. In three games, Singletary has rushed 42 times for 197 yards (4.7 average) and two touchdowns. He has two explosive plays of 20 or more yards, including a long of 43, and has converted nine first downs. In the passing game, he has nine receptions for 58 yards (6.4 average).

First-round draft pick Malik Nabers has been impressive through three games. The sixth overall pick of the 2024 NFL Draft, he has 23 receptions for 271 yards (11.8 average) and three touchdowns. He has six explosive plays of 20 or more yards, including a long of 28 yards. In a 21-18 loss at Washington in Week 2, he caught 10 passes for 127 yards and one touchdown, converting seven first downs. See which team to pick here.

How to make Cowboys vs. Giants picks

SportsLine's model is leaning Under the total, projecting 44 points. It has also generated an against-the-spread pick that hits in well over 50% of simulations. You can only get the NFL model's picks at SportsLine.

So who wins Cowboys vs. Giants on Thursday Night Football, and which side of the spread cashes in well over 50% of simulations? Visit SportsLine now to see which side of the Cowboys vs. Giants spread to jump on, all from the advanced model that is up well over $7,000 on its NFL picks, and find out.