Monday Night Football prediction, odds, time, spread, line: Chiefs vs. Saints picks from expert on 23-11 run

Danny Vithlani, on a 23-11 run on NFL picks, has revealed his Monday Night Football bets for New Orleans Saints vs. Kansas City Chiefs in Week 5

The Kansas City Chiefs are seeking their fifth 5-0 start in franchise history and first since 2018 when they battle the New Orleans Saints on Monday Night Football. Kansas City has the fourth-best record on MNF at 30-20 (.600), while New Orleans is 25-26 (.490). The Saints (2-2), who were 1-0 on Monday night in 2023, have lost their last three meetings with Kansas City. The Chiefs (4-0), who were 0-1 on MNF a year ago, are seeking their ninth consecutive AFC West title.

The game from GEHA Field at Arrowhead Stadium in Kansas City, Mo., is scheduled to kick off at 8:15 p.m. ET. Kansas City is a 5.5-point home favorite in the latest Chiefs vs. Saints odds via SportsLine Consensus, while the over/under for total points scored 43. Before making any Saints vs. Chiefs picks, make sure to check out the NFL predictions and betting advice from the SportsLine expert Danny Vithlani, considering his mastery of picks involving the NFL.

Vithlani is coming off a 27-15 debut season on NFL picks with SportsLine, and in 2024 Vithlani has gone 23-11 on his last 34 NFL picks, returning $1,086. Anyone who has followed him is way up.

Now, Vithlani has locked in on Chiefs vs. Saints and just revealed his coveted NFL picks and predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and NFL betting lines on the spread, money line and over/under for Saints vs. Chiefs:

• Chiefs vs. Saints spread: Kansas City -5.5
• Chiefs vs. Saints over/under: 43 points
• Chiefs vs. Saints money line: Kansas City -239, New Orleans +195
• NO: The Saints have hit the first-half Over in nine of their last 11 away games (+6.70 units)
• KC: The Chiefs have hit the fourth-quarter Under in 17 of their last 19 games (+14.75 units)
• Chiefs vs. Saints picks: See picks at SportsLine
• Chiefs vs. Saints streaming: FuboTV (Try for free)

Why the Chiefs can cover

Tight end Travis Kelce led Kansas City with season highs in catches (7) and receiving yards (89) last week. He will look for his third game in a row with four or more catches. Kelce had eight catches for 68 yards and a touchdown in the last meeting with New Orleans. He has five receiving TDs over his past two games on Monday Night Football and has 13 career receiving TDs on Monday, tied with Jimmy Graham for most-ever by a tight end.

Defensive tackle Chris Jones had a season-high two sacks last week, his 15th-career game with two or more sacks. He has registered a sack in three of his past four games at home. He has five sacks in his past four games on MNF. The ninth-year veteran has 78.5 career sacks in 127 games played. He also has forced 13 fumbles, including one in the season opener in a 27-20 win over the Baltimore Ravens on Sept. 5, and recovered three. See who to back at SportsLine.

Why the Saints can cover

Third-year wide receiver Chris Olave leads New Orleans in receptions and yards in 2024. He has 20 catches for 265 yards (13.3 average) and one touchdown. He has two explosive plays of 20 or more yards, including a season-high 39-yarder. He also has 77 yards after the catch and 15 first-down conversions. In the Week 4 loss at Atlanta, he caught eight passes for 87 yards with five first-down conversions.

Defensively, cornerback Alontae Taylor has been a force. He leads New Orleans with 3.5 sacks for 30 yards and is second in tackles with 24, including 18 solo. He has four tackles for loss, four pass breakups and one forced fumble. In the 15-12 loss to the Philadelphia Eagles in Week 3, he registered five tackles, including two solo, with a half-sack and forced fumble. See who to back at SportsLine.

How to make Chiefs vs. Saints picks

Vithlani has analyzed Saints vs. Chiefs from every possible angle. He's leaning Under the total and has also discovered a critical X-factor that has him jumping all over one side of the spread. Find out what it is, and which team to back, at SportsLine. 

So who wins Saints vs. Chiefs on Monday Night Football, and what critical x-factor makes one side of the spread hit hard? Visit SportsLine now to see which side of the Saints vs. Chiefs spread to back, all from the expert who is 23-11 on NFL picks, and find out.