Researchers uncover a link between impaired glutathione–ascorbate metabolism and early dopamine increases in Huntington's disease, suggesting GSTO2 as a potential therapeutic target to manage motor dysfunction.

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein-;the most important genetic risk factor for Alzheimer's disease-;the same cells cause harmful inflammation and clumps of misfolded proteins, according to a new study by scientists at Gladstone Institutes.

A team led by researchers at the University of Toronto has uncovered new targets that could be the key to effectively treating glioblastoma, a lethal type of brain cancer.

The researchers' recently published study describes a way to re-activate apoptosis in mutated cells, which would amount to forcing cancer to self-destruct through a bioengineered, bonding molecule.

A study on deep brain stimulation reveals its impact on spatial navigation, highlighting potential therapeutic avenues for cognitive deficits in aging.

Carbonic anhydrase inhibitors show potential in reducing tau protein buildup, offering new therapeutic avenues for neurodegenerative diseases like tauopathies.

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in Alzheimer’s disease.

A University of Rochester research team is reporting a new way to detect cancer cells with a "liquid biopsy" that's designed to be simpler, faster, and more informational than current methods.

A team led by researchers at the University of Toronto has discovered that a group of cells located in the skin and other areas of the body, called neural crest stem cells, are the source of reprogrammed neurons found by other researchers.

Neuroblastoma (NB), the most prevalent extracranial solid tumor in children, poses a significant therapeutic challenge due to its metastasis and high heterogeneity. A recent study leveraging single-cell RNA sequencing (scRNA-seq) has uncovered vital molecular mechanisms underlying NB's progression and metastasis, shedding light on potential therapeutic targets.

The AI tool AlphaFold has been improved so that it can now predict the shape of very large and complex protein structures. Researchers have also succeeded in integrating experimental data into the tool. The results are a step toward more efficient development of new proteins for, among other things, medical drugs.

A recent study has shown that nanoplastics – plastic particles smaller than 0.001 millimeters – affect the body's ability to absorb antibiotics, and may even lead to the growth of antibiotic-resistant bacteria.

New research has identified crucial links between dietary choices and the progression of multiple sclerosis (MS). The study explored how enzymes called ceramide synthase 5 and 6 are responsible for the toxic effect of a palm oil-rich diet on neurons in the central nervous system, which causes a subsequent increase in the severity of MS symptoms.

Our bodies divest themselves of 60 billion cells every day through a natural process called "apoptosis". So Stanford medicine researchers are developing a new approach to cancer therapy that could "trick cancer cells into disposing of themselves," according to announcement from Stanford's medical sc...

Researchers link microscopic protein structures and cellular interactions to individual differences in brain connectivity, offering new insights into brain function and variability.