Researchers uncover immune mechanism behind myocarditis from cancer immunotherapy
Some patients being treated with immune checkpoint inhibitors, a type of cancer immunotherapy, develop a dangerous form of heart inflammation called myocarditis.
Gene editing with CRISPR may introduce new defects
The CRISPR tool is capable of repairing the genetic defect responsible for the immune disease chronic granulomatous disease.
Genetic repair via CRISPR can inadvertently introduce other defects, researchers show
The CRISPR molecular scissors have the potential to revolutionize the treatment of genetic diseases. This is because they can be used to correct specific defective sections of the genome. Unfortunately, ...
AI-powered MRI predicts outcomes in prostate cancer
Researchers determine whether artificial intelligence-based MRI data could predict prostate cancer patient outcomes.
A novel synthetic lethal target for ATM inhibitors in pancreatic cancer
A novel discovery in the field of pancreatic cancer treatment has been unveiled, revealing the epigenetic silencing of BEND4 as a potential synthetic lethal marker for enhancing the efficacy of ATM inhibitors in pancreatic cancer treatment.
Advances in neutropenia research could pave the way for better treatments
Neutropenia is a condition in which there are not enough neutrophils, a type of white blood cell, in the blood.
Genetic and environmental drivers shape early type 1 diabetes risk in children
Researchers from the TEDDY study highlight how specific genetic and environmental factors may drive early autoimmunity linked to type 1 diabetes in children, emphasizing distinct patterns for different autoantibodies.
How cancer immunotherapy may cause heart inflammation in some patients
Some patients being treated with immune checkpoint inhibitors, a type of cancer immunotherapy, develop a dangerous form of heart inflammation called myocarditis. Researchers have now uncovered the immune basis of this inflammation. The team identified changes in specific types of immune and stromal cells in the heart that underlie myocarditis and pinpointed factors in the blood that may indicate whether a patient's myocarditis is likely to lead to death.
Onc.AI Serial Imaging Response Score Outperforms Traditional Methods for Early Assessment of NSCLC Immunotherapy Outcomes
Multi-institutional study presented at the SITC annual meeting highlights the ability of Onc.AI’s imaging-based biomarker to improve identification of long-term survivors at first follow up (HR 0.33).
Curcumin compound reactivates Epstein–Barr virus, offering safer cancer therapy
A novel curcumin derivative, C210, activates the Epstein–Barr virus (EBV) lytic cycle without producing infectious virions by disrupting HSP90. This discovery opens avenues for safer EBV-positive cancer therapies.
Modulating CD39 expression to enhance CAR-T cell therapy against hepatocellular carcinoma
In the quest to enhance the efficacy of chimeric antigen receptor T (CAR-T) cell therapy against hepatocellular carcinoma (HCC), a recent study has identified a pivotal role for CD39 expression in modulating the function of CAR-T cells.
New active substance shows promise in treating acute sudden hearing loss
A research team led by MedUni Vienna has investigated AC102, a new active substance that offers hope of an effective treatment for acute sudden hearing loss. The latest results have been published in the scientific journal "Cell Death & Disease".
Revised diagnostic criteria seek to avoid over-diagnosis of Alzheimer’s disease
Diagnosis of Alzheimer's Disease (AD) is currently largely based on the presence of biomarkers. This may lead to a problematic over-diagnosis if this is incorrectly interpreted.
last updated on 6 Nov 22:32