Thursday Night Football betting guide, odds: 49ers vs. Seahawks expert, model, AI team up for 5-1 TNF parlay

Build the perfect Thursday Night Football parlay for Seattle vs. San Francisco using SportsLine's NFL model, NFL experts, and self-learning NFL AI picks

The Week 6 NFL schedule has arrived with Thursday Night Football putting the spotlight on an NFC West showdown featuring the San Francisco 49ers (2-3) visiting the division-leading Seattle Seahawks (3-2) at Lumen Field. The 49ers remain the betting favorite to win the NFC West (-115), despite the Seahawks' (+220) current first-place status, and San Francisco enters Week 6 TNF as a road favorite on the money line (-185) and against the spread (-3.5) in the latest 49ers vs. Seahawks odds.

Both teams are dealing with NFL injuries and should be hungry coming off surprising defeats, but the Seahawks might have even more to prove in front of the "12th man" as home underdogs looking to avenge two double-digit losses to the 49ers last season. With such a critical divisional matchup and explosive players like DK Metcalf, Kenneth Walker III, Deebo Samuel and Brandon Aiyuk involved, there is plenty on the board for your NFL picks, props and parlays.

SportsLine crunched the numbers and analyzed all the latest information and its proven computer model, experts and AI PickBot locked in selections for the optimal Week 6 Thursday Night Football picks and parlay. Go even deeper on 49ers vs. Seahawks betting at SportsLine. 

Leg 1: Thursday Night Football Computer Pick

The SportsLine computer model simulates every NFL game 10,000 times factoring in everything from stats and trends to tendencies and injuries. The model's best bets ("A" picks) have returned over $7,000 for $100 players since its inception and are a blistering 10-2 this season.

In its Week 6 TNF simulations, Seattle covers the spread 53% of the time, which makes them a slight lean ("C" pick) with the points.

The Pick: Seahawks +3.5 (-117)

Want more? The model also has ATS and money-line picks for TNF, plus there are multiple must-see "A" picks for Sunday's NFL games that you'll want to pounce on before the odds move. Head to SportsLine to see them all.

Leg 2: Thursday Night Football Expert Pick

SportsLine's Micah Roberts is a former bookmaker and sports-betting veteran who has a track record of success, including going 23-5 on his last 28 picks involving the 49ers.

Roberts is leaning towards this game being a shootout. One side gets out to an early lead and the other chases back with late points to push it over.

The Pick: Over 47.5 (-111)

Want more? Micah also locked in a strong TNF pick against the spread (see it right here) that is backed by his fellow expert, Larry Hartstein, who is a scorching 13-2 in his last 15 NFL picks. See all the 49ers vs. Seahawks expert picks at SportsLine.

Leg 3: Thursday Night Football AI Pick

SportsLine's AI PickBot is a proprietary real-time machine learning model that finds the value picks for each game, including hitting nearly 1,700 of its top prop picks in 2023.

It has a 4-star pick for Brock Purdy, but on the ground where he has gone over his rushing yards total in the last five games, averaging 21.6 yards per game.

The Pick: Brock Purdy Over 12.5 Total Rushing Yards (-123)

Want more? The AI PickBot has more 4.5 and 5-star prop picks for NFL Week 6, plus, it has spread, total and money-line picks for every game on the board. See all the AI picks at SportsLine. 

The total payout of SportsLine's Thursday Night Football parlay involving model, expert and AI picks is +539.

If you are looking for more NFL picks and parlays or season-long and daily fantasy lineup advice, join SportsLine here to get exclusive members-only best bets from its proven model, AI PickBot and team of more than 40 experts.