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College football odds, picks, lines, bets, predictions for Week 6, 2024: Proven model backs Iowa, California

SportsLine's advanced computer model has revealed its 2024 Week 6 college football picks

02 Oct 2024, 06:30 · CBS Sports

Michigan State will face an elite team for the second week in a row when it travels to No. 6 Oregon on Friday night during the Week 6 college football schedule. The Spartans are coming off a 38-7 blowout loss against No. 3 Ohio State, and they are 24-point underdogs in the Week 6 college football odds. Oregon struggled in its first two games of the season, but it bounced back with convincing road wins against Oregon State and UCLA. Should you back the Ducks with your Week 6 college football bets?

There are no ranked vs. ranked matchups on Saturday, but there are several intriguing matchups featuring top-ranked teams. No. 9 Missouri (+2.5) travels to Texas A&M, No. 4 Tennessee (-13.5) goes to Arkansas, and No. 10 Michigan (+2.5) heads to Washington. Before locking in any Week 6 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks. It also went a sizzling 6-0 on all top-rated college football picks in Week 5. Anyone who has followed it has seen strong returns.

Now, it has turned its attention to the latest college football odds and Week 6 college football betting lines on the spread, money line and over/under. Head here to see every pick.

Top college football predictions for Week 6

One of the college picks the model is high on during Week 6: Iowa (+19.5) stays within the big spread at No. 3 Ohio State in a 3:30 p.m. ET matchup Saturday on CBS. The Buckeyes chose to play a weak non-conference schedule this season, facing no real opposition through the first three weeks of the campaign. They opened conference play with a comfortable win at Michigan State, but they are facing a better opponent on Saturday.

Iowa is coming off its best performance of the season, cruising to a 31-14 win at Minnesota as a 2.5-point favorite. Junior running back Kaleb Johnson continued his phenomenal start, racking up 206 rushing yards and three touchdowns on 21 carries. He has finished with at least 119 rushing yards and two touchdowns in every game this season, and he is a big reason why the model has Iowa covering the spread in well over 50% of simulations. See the rest of its Week 6 college football picks here.

Another prediction: California (+10) plays a one-score game against No. 8 Miami in a 10:30 p.m. ET kickoff on Saturday. The Hurricanes narrowly avoided a massive upset last week, getting past Virginia Tech in a 38-34 final as 17.5-point favorites. They have now covered the spread just four times in their last 17 conference games, making them a team to fade on the road following that emotional victory.

California had its three-game winning streak snapped in a 19-14 loss at Florida State its last time out, but it had an extra week to recover after that game. Sophomore quarterback Fernando Mendoza has thrown for 892 yards and five touchdowns, with four of his receivers hitting the 100-yard mark. The Golden Bears have won five of their last seven home games, and they are covering the spread in nearly 60% of the latest simulations. See picks for every other game in Week 6 here.

How to make college football picks for Week 6

The model has also made the call on who wins and covers in every FBS matchup in Week 6, and it's calling for a whopping seven underdogs to win outright, including an upset in one of the biggest games of the week. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which seven underdogs win outright in Week 6? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.