Multitarget stool DNA test shows promise for early colorectal cancer detection
· News-MedicalA recent prospective cross-sectional study in Thailand demonstrates that multitarget stool DNA testing is highly sensitive and specific for detecting colorectal cancer (CRC) among Thai individuals. Researchers believe that this testing method could serve as a viable non-invasive alternative to colonoscopy, especially in settings where colonoscopy is less accessible or less accepted by patients.
In the study, data from 274 patients (mean age 62 years, with a predominantly female cohort at 60.6%) were evaluated. Colorectal cancer was identified in 17.2% of participants, while 6.2% were found to have advanced adenomas, which are precursors to cancer. The multitarget stool DNA test, a non-invasive screening method, yielded impressive results: it detected CRC with a sensitivity of 91.5% and a specificity of 90.3%, accurately identifying cancer in over 90% of cases. The test's sensitivity was consistent across both right-sided and left-sided colon lesions, at 92.3% and 91.2%, respectively.
For advanced colorectal neoplasms, which include both CRC and advanced adenomas, the test demonstrated a sensitivity of 75% and a specificity of 91.9%, marking it as a promising tool for the early detection of serious colorectal conditions. These findings highlight the test's potential as an effective screening option for detecting CRC, especially for larger lesions, although some limitations remain for detecting smaller-sized abnormalities.
BGI Genomics' COLOTECT® stool DNA testing kits were used for sample and raw data collection. COLOTECT® is a non-invasive tool for early colorectal cancer detection based on DNA methylation testing, targeting the methylation profile of colorectal exfoliated cells to assess the risk of colorectal cancer and advanced adenomas. This tool requires no special equipment, imposes no dietary restrictions, and is entirely non-invasive. In recent years, DNA methylation-based colorectal cancer detection has gained recognition, being incorporated into multiple CRC screening guidelines and expert consensus worldwide.
The study results indicate that multitarget stool DNA testing is highly sensitive and specific for CRC detection among Thai individuals. This testing could provide a viable non-invasive alternative to colonoscopy, especially in settings where colonoscopy is less accessible or less accepted by patients.
As early as 2022, BGI Genomics Southeast Asia team established a close partnership with Professor Varut Lohsiriwat from the Faculty of Medicine, Siriraj Hospital, Mahidol University, inviting him to participate in the BGI Genomics overseas science education program "Your Health, Our Concern." In this program, Professor Lohsiriwat shared valuable knowledge and insights on colorectal cancer treatment.
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